Conditional lethal mutants of adenovirus type 2-simian virus 40 hybrids. II. Ad2+ND1 host-range mutants that synthesize fragments of the Ad2+ND1 30K protein
نویسندگان
چکیده
منابع مشابه
Use of nondefective adenovirus-simian virus 40 hybrids for mapping the simian virus 40 genome.
A series of viable recombinants between adenovirus 2 (Ad2) and simian virus 40 (SV40) (nondefective Ad2-SV40 hybrids) have been isolated. The members of this series (designated Ad2(+)ND(1) through Ad2(+)ND(5)) differ from one another in the early SV40-specific antigens and the SV40-specific RNA species which they induce in infected cells. They also contain different amounts of SV40 DNA as shown...
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A line of polyoma-transformed mouse cells has been isolated which is fully susceptible to lytic infection by polyoma virus. This line has been used to select virus mutants which have lost most or all of their ability to grow in the untransformed parental line while retaining the ability to grow in the transformed derivative. These virus mutants are also defective in their ability to transform c...
متن کاملBiological activities of deletion mutants of simian virus 40.
Mutants of Simian virus 40 (SV40) with large deletions in the early or late regions of the genome were tested for biological activity. Deletion mutants lacking portions of both late genes (B/C and D), but with an intact early genomic segment, were able to induce T antigen in infected cells, replicate their DNA in the absence of helper virus, stimulate thymidine incorporation into cellular DNA, ...
متن کاملControl of simian virus 40 gene expression in adenovirus-simian virus 40 hybrid viruses. Synthesis of hybrid adenovirus 2-simian virus 40 RNA molecules in cells infected with a nondefective adenovirus 2-simian virus 40 hybrid virus.
The effect of interferon on simian virus 40 (SV40) and adenovirus 2 (Ad2) T antigen synthesis has been examined in cells infected with SV40, with Ad2, and with a nondefective Ad2-SV40 hybrid virus, Ad2(+)ND(4). The induction of SV40 T antigen by SV40 was highly sensitive to interferon, whereas the induction of Ad2 T-antigen by Ad2 was resistant. This difference in interferon sensitivity was als...
متن کاملProposal for a uniform nomenclature for simian virus 40 mutants.
A uniform nomenclature for simian virus 40 mutants has been developed. This nomenclature should evolve into a comprehensive nomenclature as new mutants and information are obtained. Hopefully, his nomenclature will also stimulate the development of a comprehensive nomenclature for all animal virus mutants.
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1976
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.19.2.559-571.1976